In the cyber-physical system （CPS）， the traditional multi-source heterogeneous data integration model is difficult to map the conceptual layer between heterogeneous systems through middleware， which has the problems of low transmission performance and difficult system expansion. Due to the challenges above， a CPS-oriented heterogeneous data integration model is proposed. The data object model is designed to realize the high-level concept mapping between physical and simulation systems. The monitoring and control metadata are defined and the incremental or full field updates for different data types are used to reduce network load. A communication model of system is designed based on the Protobuf protocol to improve the system expansion capability. Based on the data interaction model and high level architecture （HLA）/data distribution service （DDS） system middleware， a CPS prototype system is implemented， which verifies the usability of the model and compares the compression performance of the message.