Most of psychophysiological computing （PPC） studies are under the experimental environments of synchronization theory hypothesis， however neurophysiological representations have asynchronous properties， which cannot be precisely and effectively described in real time using synchronized recording technology. It is being the first issue of PPC to resolve how to recode these asynchronous multi-modality neurophysiological activities with low-power， low-redundancy， real-time and accurate. For this issue， this study focuses on the goals of microscopic neurophysiological activities and macroscopic psychological variables， resolves the design challenges of asynchronous multimodality physiological information recording scheme and corresponding passive physiological signals sensing technology， and designs and develops the first asynchronous physiological process unit （PPU）. The PPU has the characteristics of low power consumption， high time series precision， high computing performance and strong anti-interference ability. Finally，we look forward to the future of PPU applied in the research area of brain science and brain-like computing.