To improve the treatment precision of focused ultrasound， two traveling wave focusing （TWF） transducers with the same frequency of 0.6 MHz are placed in opposite direction coaxially and confocally to realize standing wave focusing （SWF）. Combining with the numerical simulation of sound field， cavitation and nonlinear research， lesion changes in tissue-mimicking phantom and the formation mechanism of lesion during SWF and TWF ultrasonic irradiation are compared under the same peak focus acoustic pressure about 17 MPa. The results demonstrate that the size of initial lesion formed by SWF ultrasonic irradiation is 0.18λ×0.25λ， which is significant smaller than that of TWF， 0.91λ×0.3λ， under the same peak focus acoustic pressure. But the surface sound pressure of the SWF transducers is only 0.46 times that of TWF. It shows that SWF can significantly compress the lesion size in the transverse direction and can protect organs and tissues by reducing the amplitude of acoustic pressure. And the lesion caused by TWF ultrasound appeared faster than SWF， which is related to the strong nonlinear effect of TWF. The results in this paper show that SWF can achieve more precise lesion than TWF， and the acoustic path is safer， which provides a theoretical reference for the application of SWF in clinic.