基于可变形注意力和多尺度多实例学习的全切片病理图像分类方法
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南京航空航天大学人工智能学院脑机智能技术教育部重点实验室,南京211106

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Whole-Slide Pathology Image Classification Method Based on Deformable Attention and Multi-Scale Multi-Instance Learning
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Key Laboratory of Brain‑Machine Intelligence Technology, Ministry of Education, College of Artificial Intelligence, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China

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    摘要:

    全切片病理图像(Whole Slide Images, WSIs)是病理学诊断的金标准。准确的组织病理图像分类为肿瘤的类型、分级和分期提供了详细信息,对癌症预后和治疗策略选择具有重要意义。目前,在计算病理学领域中,基于多实例学习(Multi-Instance Learning, MIL)的分析方法正成为针对全切片病理图像分类问题的主流方法,但该方法大多针对单一尺度病理图像展开,无法在不同层次上理解癌症的产生与发展机制。此外,病理图像的高分辨率特性以及不同尺度病理图像蕴含信息的差异性,也给高效分析单一尺度内的病理图像块以及融合不同尺度下的病理信息带来挑战。为此,本文提出了一种基于可变形注意力和多尺度多实例学习的全切片病理图像分类方法(DMSMIL)。具体而言,该方法通过设计可变形注意力分支学习尺度内不同图像块的关联,提升了注意力计算的效率。同时,设计了基于最优传输(Optimal Transport, OT)的关联算法融合不同尺度的病理图像,实现了对多尺度病理信息的高效对齐。在乳腺癌亚型分类和肺癌亚型分类任务上的实验结果表明,所提方法取得了85.39%和92.00%的分类准确率,相较于主流的全切片病理图像分类方法性能得到了显著提升。

    Abstract:

    Whole Slide Images(WSIs) are generally considered the golden standard for pathological diagnosis. Accurate classification of WSIs provides detailed information on tumor type, grade, and stage, which is crucial for cancer prognosis and treatment strategy selection. Currently, in the field of computational pathology, analysis methods based on Multi-Instance Learning (MIL) are becoming the mainstream approach for the classification of Whole-Slide Pathological Images. However, these methods mostly focus on single-scale pathological images, which limits the understanding of the mechanisms of cancer development and progression at different levels. Additionally, the high-resolution nature of pathological images and the information discrepancies across different scales pose challenges for efficiently integrating and analyzing pathological image patches within a single scale as well as across multiple scales. To address these issues, this paper proposes a whole-slide pathology image classification method based on deformable attention and multi-scale multi-instance learning (DMSMIL). Specifically, this method enhances the efficiency of attention computation by designing a deformable attention branch to learn the associations among image patches within the same scale. Meanwhile, an association algorithm based on Optimal Transport (OT) is designed to integrate pathological images across different scales, achieving efficient alignment of multi-scale pathological information. Experimental results on breast cancer subtype classification and lung cancer subtype classification tasks show that the proposed method achieved classification accuracy of 85.39% and 92.00% respectively, showing improved performance compared to mainstream whole slide image classification methods.

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薛 保,周俊杰,邵 伟.基于可变形注意力和多尺度多实例学习的全切片病理图像分类方法[J].数据采集与处理,,():

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  • 在线发布日期: 2025-09-15