To investigate the discrepancies in brain function of first-episode depressed p atients, five first-episode depressed patients and one healthy volunteer of the same a ge undergo resting state functional magnetic resonance imaging (fMRI) scans by Si emens 3.0T and collecting data are anylized by the amplitude of low frequency f luctuation (ALFF). Then, the ALFF results are possessed by two sample t te s t. The result shows the ALFF value of t he depressed group are decreased in the particular areas, including the left cer ebellar lobe, the left superior temporal gyrus, the bilateral caudate nucleus, t he right lingual gyrus, the left superior frontal gyrus, the right rolandic oper c ulu m, the right anterior cingulate gyri, the right middle frontal gyrus, the right in ferior frontal gyrus, the right supplementary motor area, the left superior parietal gyrus, and the right postcentral gyrus. The research result suggests that the first episode depressed patients have functional discrepancies in the frontal lobe, th e temporal lobe,the cingulate gyrus and the caudate nucleus. These areas are dir ectly correlated with emotion, cognition and memory. Abnormalities in these area s are closely bound up with depression.