基于内源光信号的纤维光学内镜设计
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作者单位:

1.南京航空航天大学自动化学院,南京 211106;2.南京工程学院计算机工程学院,南京 211167

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国家自然科学基金(61875085)资助项目;国家自然科学基金重大科研仪器研制(81727804, 81827803)资助项目。


Design of Fiber Optic Endoscope Based on Optical Intrinsic Signal
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Affiliation:

1.College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China;2.Department of Computer Engineering, Nanjing Institute of Technology, Nanjing 211167, China

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    摘要:

    内镜检查是临床消化道疾病诊疗的最主要手段,其功能是获取组织的结构信息。在消化道疾病的发生和发展过程中通常伴随着功能信息如血氧及与代谢相关参数的改变。论文基于内源光信号成像技术开发了一套纤维光学内镜系统,能够测量生物组织氧合血红蛋白、脱氧血红蛋白、细胞色素C、细胞色素氧化酶、黄素腺嘌呤二核苷酸(Flavin adenine dinucleotide, FAD)和散射特性等6种功能信息的变化量。设计注射过量亚硝酸钠(800 mg/kg)的小鼠实验,利用所设计的纤维光学内镜成功获得了注射药物3、6、9、12、15以及18 min后同视野、在体的血氧及与代谢相关参数图像。实验模型的氧合血红蛋白含量持续减少,脱氧血红蛋白的含量持续增加。研究表明内源光信号的纤维光学内镜系统能够准确反映生物组织功能信息的变化规律。

    Abstract:

    Endoscopy is the main method in the clinical diagnosis and treatment of gastrointestinal diseases. Its function is to obtain the structural information of the tissue. The occurrence and development of digestive diseases are usually accompanied by the changes of functional information, such as blood oxygen and metabolic parameters. This paper develops a fiber optic endoscopy system based on endogenous optical signal imaging technology, which can measure changes of six types of functional information including biological tissue oxy-hemoglobin, deoxy-hemoglobin, cytochrome C, cytochrome oxidase, FAD and scattering characteristics for biological tissues. In this study, we designed an in-vivo animal experiment with injection of excessive sodium nitrite. Then, the designed fiber optic endoscopy system was utilized to obtain the blood oxygen and metabolism related parameters in the same field at 3, 6, 9, 12, 15 and 18 min time points during drug injection. The concentration of oxyhemoglobin in the experimental model continued to decrease, while that of deoxyhemoglobin continued to increase. Research shows that the fiber optic endoscopy system based on intrinsic optical signal can accurately reflect the change of biological tissue function information.

    表 4 Table 4 Homogeneity of Beijing-Tianjin-Hebei airport group in 201X by baseline method
    表 1 Table 1 Airport network related data example
    图1 Airport attribute network diagramFig.1
    图2 Network representation learning of airport attributeFig.2
    图3 Homogeneity degree of Beijing-Tianjin-Hebei multi-airport system based on baseline algorithm[10] shown in heat mapFig.3
    图4 Homogeneity degree of Beijing-Tianjin-Hebei airport group based on learning method of attribute network representation shown in heat mapFig.4
    图1 基于内源光信号的纤维光学内镜系统Fig.1 Fiber optic endoscopy system based on endogenous optical signal
    图2 波长原始图Fig.2 Original wavelength map
    图3 生色团浓度变化图Fig.3 Changes of chromophores map
    图4 氧合血红蛋白浓度变化量随时间变化图像Fig.4 Images of oxy-hemoglobin concentration change with time
    图5 脱氧血红蛋白浓度变化量随时间变化图像Fig.5 Images of deoxyhemoglobin concentration change with time
    图6 氧合血红蛋白浓度变化量随时间变化曲线Fig.6 Oxy-hemoglobin concentration variation with time
    图7 脱氧血红蛋白浓度变化量随时间变化曲线Fig.7 Hemoglobin concentration variation with time
    表 2 Table 2 Examples of province and administrative region in China
    表 3 Table 3 Experimental data of airport attribute information
    表 5 Table 5 Homogeneity of Beijing-Tianjin-Hebei airport group in 201X by the proposed method
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李韪韬,宁雪,张欢,张雅檬,钱志余.基于内源光信号的纤维光学内镜设计[J].数据采集与处理,2021,36(4):705-712

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  • 收稿日期:2021-04-23
  • 最后修改日期:2021-05-18
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  • 在线发布日期: 2021-09-23